AustralieFrV1, Main, Exploration, bibRecord, 000B68

Gene–environment interactions involving functional variants: Results from the Breast Cancer Association Consortium

Identifieur interne : 000B68 ( Main/Exploration ); précédent : 000B67; suivant : 000B69

Gene–environment interactions involving functional variants: Results from the Breast Cancer Association Consortium

Auteurs : Myrto Barrdahl ; Anja Rudolph ; John L. Hopper ; Melissa C. Southey ; Annegien Broeks ; Peter A. Fasching ; Matthias W. Beckmann ; Manuela Gago-Dominguez ; J. Esteban Castelao ; Pascal Guénel ; Thérèse Truong ; Stig E. Bojesen ; Susan M. Gapstur ; Mia M. Gaudet ; Hermann Brenner ; Volker Arndt ; Hiltrud Brauch ; Ute Hamann ; Arto Mannermaa ; Diether Lambrechts ; Lynn Jongen ; Dieter Flesch-Janys ; Kathrin Thoene ; Fergus J. Couch ; Graham G. Giles ; Jacques Simard ; Mark S. Goldberg ; Jonine Figueroa ; Kyriaki Michailidou ; Manjeet K. Bolla ; Joe Dennis ; Qin Wang ; Ursula Eilber ; Sabine Behrens ; Kamila Czene ; Per Hall ; Angela Cox ; Simon Cross ; Anthony Swerdlow ; Minouk J. Schoemaker ; Alison M. Dunning ; Rudolf Kaaks ; Paul D. P. Pharoah ; Marjanka Schmidt ; Montserrat Garcia-Closas ; Douglas F. Easton ; Roger L. Milne ; Jenny Chang-Claude

Source :

International Journal of Cancer [ 0020-7136 ] ; 2017.

RBID : PMC:5601244

Descripteurs français

English descriptors

KwdEn :
- Alcohol Drinking (genetics), Breast Neoplasms (epidemiology), Breast Neoplasms (genetics), Breast Neoplasms (pathology), CASP8 and FADD-Like Apoptosis Regulating Protein (genetics), Estrogen Receptor alpha (genetics), Female, Gene-Environment Interaction, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Polymorphism, Single Nucleotide, Risk Factors, Smoking (genetics).
MESH :
- chemical , genetics : CASP8 and FADD-Like Apoptosis Regulating Protein, Estrogen Receptor alpha.
- epidemiology : Breast Neoplasms.
- genetics : Alcohol Drinking, Breast Neoplasms, Smoking.
- pathology : Breast Neoplasms.
- Female, Gene-Environment Interaction, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Polymorphism, Single Nucleotide, Risk Factors.

Abstract

Investigating the most likely causal variants identified by fine‐mapping analyses may improve the power to detect gene–environment interactions. We assessed the interplay between 70 single nucleotide polymorphisms identified by genetic fine‐scale mapping of susceptibility loci and 11 epidemiological breast cancer risk factors in relation to breast cancer. Analyses were conducted on up to 58,573 subjects (26,968 cases and 31,605 controls) from the Breast Cancer Association Consortium, in one of the largest studies of its kind. Analyses were carried out separately for estrogen receptor (ER) positive (ER+) and ER negative (ER–) disease. The Bayesian False Discovery Probability (BFDP) was computed to assess the noteworthiness of the results. Four potential gene–environment interactions were identified as noteworthy (BFDP < 0.80) when assuming a true prior interaction probability of 0.01. The strongest interaction result in relation to overall breast cancer risk was found between CFLAR‐rs7558475 and current smoking (OR_int = 0.77, 95% CI: 0.67–0.88, p_int = 1.8 × 10⁻⁴). The interaction with the strongest statistical evidence was found between 5q14‐rs7707921 and alcohol consumption (OR_int =1.36, 95% CI: 1.16–1.59, p_int = 1.9 × 10⁻⁵) in relation to ER– disease risk. The remaining two gene–environment interactions were also identified in relation to ER– breast cancer risk and were found between 3p21‐rs6796502 and age at menarche (OR_int = 1.26, 95% CI: 1.12–1.43, p_int =1.8 × 10⁻⁴) and between 8q23‐rs13267382 and age at first full‐term pregnancy (OR_int = 0.89, 95% CI: 0.83–0.95, p_int = 5.2 × 10⁻⁴). While these results do not suggest any strong gene–environment interactions, our results may still be useful to inform experimental studies. These may in turn, shed light on the potential interactions observed.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601244

DOI: 10.1002/ijc.30859
PubMed: 28670784
PubMed Central: 5601244

Affiliations:

Le document en format XML

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<author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name>
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<author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name>
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<author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name>
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<author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
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<author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name>
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</author>
<author><name sortKey="Goldberg, Mark S" sort="Goldberg, Mark S" uniqKey="Goldberg M" first="Mark S." last="Goldberg">Mark S. Goldberg</name>
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</affiliation>
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<author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name>
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<affiliation><nlm:aff id="ijc30859-aff-0035"></nlm:aff>
</affiliation>
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<author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name>
<affiliation><nlm:aff id="ijc30859-aff-0036"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="ijc30859-aff-0037"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name>
<affiliation><nlm:aff id="ijc30859-aff-0036"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name>
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</affiliation>
</author>
<author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name>
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</affiliation>
</author>
<author><name sortKey="Eilber, Ursula" sort="Eilber, Ursula" uniqKey="Eilber U" first="Ursula" last="Eilber">Ursula Eilber</name>
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</affiliation>
</author>
<author><name sortKey="Behrens, Sabine" sort="Behrens, Sabine" uniqKey="Behrens S" first="Sabine" last="Behrens">Sabine Behrens</name>
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</affiliation>
</author>
<author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name>
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</author>
<author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name>
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</author>
<author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name>
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<author><name sortKey="Cross, Simon" sort="Cross, Simon" uniqKey="Cross S" first="Simon" last="Cross">Simon Cross</name>
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</affiliation>
</author>
<author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name>
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<affiliation><nlm:aff id="ijc30859-aff-0042"></nlm:aff>
</affiliation>
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<author><name sortKey="Schoemaker, Minouk J" sort="Schoemaker, Minouk J" uniqKey="Schoemaker M" first="Minouk J." last="Schoemaker">Minouk J. Schoemaker</name>
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</affiliation>
</author>
<author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name>
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</affiliation>
</author>
<author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name>
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</affiliation>
</author>
<author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name>
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<affiliation><nlm:aff id="ijc30859-aff-0043"></nlm:aff>
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<author><name sortKey="Schmidt, Marjanka" sort="Schmidt, Marjanka" uniqKey="Schmidt M" first="Marjanka" last="Schmidt">Marjanka Schmidt</name>
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<author><name sortKey="Garcia Losas, Montserrat" sort="Garcia Losas, Montserrat" uniqKey="Garcia Losas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name>
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</affiliation>
</author>
<author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
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</affiliation>
<affiliation><nlm:aff id="ijc30859-aff-0043"></nlm:aff>
</affiliation>
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<author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name>
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</affiliation>
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</affiliation>
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<author><name sortKey="Chang Laude, Jenny" sort="Chang Laude, Jenny" uniqKey="Chang Laude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
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</affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Gene–environment interactions involving functional variants: Results from the Breast Cancer Association Consortium</title>
<author><name sortKey="Barrdahl, Myrto" sort="Barrdahl, Myrto" uniqKey="Barrdahl M" first="Myrto" last="Barrdahl">Myrto Barrdahl</name>
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<author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name>
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<author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
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<author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name>
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<author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name>
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<author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name>
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<author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name>
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<author><name sortKey="Gago Ominguez, Manuela" sort="Gago Ominguez, Manuela" uniqKey="Gago Ominguez M" first="Manuela" last="Gago-Dominguez">Manuela Gago-Dominguez</name>
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<affiliation><nlm:aff id="ijc30859-aff-0008"></nlm:aff>
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<author><name sortKey="Castelao, J Esteban" sort="Castelao, J Esteban" uniqKey="Castelao J" first="J. Esteban" last="Castelao">J. Esteban Castelao</name>
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</affiliation>
</author>
<author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name>
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</affiliation>
</author>
<author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name>
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</affiliation>
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<author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name>
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<affiliation><nlm:aff id="ijc30859-aff-0012"></nlm:aff>
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</affiliation>
</author>
<author><name sortKey="Gapstur, Susan M" sort="Gapstur, Susan M" uniqKey="Gapstur S" first="Susan M." last="Gapstur">Susan M. Gapstur</name>
<affiliation><nlm:aff id="ijc30859-aff-0014"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M." last="Gaudet">Mia M. Gaudet</name>
<affiliation><nlm:aff id="ijc30859-aff-0014"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name>
<affiliation><nlm:aff id="ijc30859-aff-0015"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="ijc30859-aff-0016"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="ijc30859-aff-0017"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name>
<affiliation><nlm:aff id="ijc30859-aff-0015"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name>
<affiliation><nlm:aff id="ijc30859-aff-0017"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="ijc30859-aff-0018"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="ijc30859-aff-0019"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name>
<affiliation><nlm:aff id="ijc30859-aff-0020"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name>
<affiliation><nlm:aff id="ijc30859-aff-0021"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="ijc30859-aff-0022"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="ijc30859-aff-0023"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name>
<affiliation><nlm:aff id="ijc30859-aff-0024"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="ijc30859-aff-0025"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jongen, Lynn" sort="Jongen, Lynn" uniqKey="Jongen L" first="Lynn" last="Jongen">Lynn Jongen</name>
<affiliation><nlm:aff id="ijc30859-aff-0026"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Flesch Anys, Dieter" sort="Flesch Anys, Dieter" uniqKey="Flesch Anys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name>
<affiliation><nlm:aff id="ijc30859-aff-0027"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="ijc30859-aff-0028"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Thoene, Kathrin" sort="Thoene, Kathrin" uniqKey="Thoene K" first="Kathrin" last="Thoene">Kathrin Thoene</name>
<affiliation><nlm:aff id="ijc30859-aff-0028"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name>
<affiliation><nlm:aff id="ijc30859-aff-0029"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
<affiliation><nlm:aff id="ijc30859-aff-0002"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="ijc30859-aff-0030"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name>
<affiliation><nlm:aff id="ijc30859-aff-0031"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Goldberg, Mark S" sort="Goldberg, Mark S" uniqKey="Goldberg M" first="Mark S." last="Goldberg">Mark S. Goldberg</name>
<affiliation><nlm:aff id="ijc30859-aff-0032"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="ijc30859-aff-0033"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name>
<affiliation><nlm:aff id="ijc30859-aff-0034"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="ijc30859-aff-0035"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name>
<affiliation><nlm:aff id="ijc30859-aff-0036"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="ijc30859-aff-0037"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name>
<affiliation><nlm:aff id="ijc30859-aff-0036"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name>
<affiliation><nlm:aff id="ijc30859-aff-0036"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name>
<affiliation><nlm:aff id="ijc30859-aff-0036"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Eilber, Ursula" sort="Eilber, Ursula" uniqKey="Eilber U" first="Ursula" last="Eilber">Ursula Eilber</name>
<affiliation><nlm:aff id="ijc30859-aff-0001"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Behrens, Sabine" sort="Behrens, Sabine" uniqKey="Behrens S" first="Sabine" last="Behrens">Sabine Behrens</name>
<affiliation><nlm:aff id="ijc30859-aff-0001"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name>
<affiliation><nlm:aff id="ijc30859-aff-0038"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name>
<affiliation><nlm:aff id="ijc30859-aff-0038"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name>
<affiliation><nlm:aff id="ijc30859-aff-0039"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cross, Simon" sort="Cross, Simon" uniqKey="Cross S" first="Simon" last="Cross">Simon Cross</name>
<affiliation><nlm:aff id="ijc30859-aff-0040"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name>
<affiliation><nlm:aff id="ijc30859-aff-0041"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="ijc30859-aff-0042"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schoemaker, Minouk J" sort="Schoemaker, Minouk J" uniqKey="Schoemaker M" first="Minouk J." last="Schoemaker">Minouk J. Schoemaker</name>
<affiliation><nlm:aff id="ijc30859-aff-0042"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name>
<affiliation><nlm:aff id="ijc30859-aff-0043"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name>
<affiliation><nlm:aff id="ijc30859-aff-0001"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name>
<affiliation><nlm:aff id="ijc30859-aff-0036"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="ijc30859-aff-0043"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schmidt, Marjanka" sort="Schmidt, Marjanka" uniqKey="Schmidt M" first="Marjanka" last="Schmidt">Marjanka Schmidt</name>
<affiliation><nlm:aff id="ijc30859-aff-0004"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="ijc30859-aff-0044"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Garcia Losas, Montserrat" sort="Garcia Losas, Montserrat" uniqKey="Garcia Losas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name>
<affiliation><nlm:aff id="ijc30859-aff-0035"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
<affiliation><nlm:aff id="ijc30859-aff-0036"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="ijc30859-aff-0043"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name>
<affiliation><nlm:aff id="ijc30859-aff-0002"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="ijc30859-aff-0030"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chang Laude, Jenny" sort="Chang Laude, Jenny" uniqKey="Chang Laude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
<affiliation><nlm:aff id="ijc30859-aff-0001"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="ijc30859-aff-0045"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">International Journal of Cancer</title>
<idno type="ISSN">0020-7136</idno>
<idno type="eISSN">1097-0215</idno>
<imprint><date when="2017">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alcohol Drinking (genetics)</term>
<term>Breast Neoplasms (epidemiology)</term>
<term>Breast Neoplasms (genetics)</term>
<term>Breast Neoplasms (pathology)</term>
<term>CASP8 and FADD-Like Apoptosis Regulating Protein (genetics)</term>
<term>Estrogen Receptor alpha (genetics)</term>
<term>Female</term>
<term>Gene-Environment Interaction</term>
<term>Genetic Association Studies</term>
<term>Genetic Predisposition to Disease</term>
<term>Humans</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Risk Factors</term>
<term>Smoking (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Consommation d'alcool (génétique)</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Humains</term>
<term>Interaction entre gènes et environnement</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Protéine de régulation de l'apoptose CASP8 et FADD-like (génétique)</term>
<term>Prédisposition génétique à une maladie</term>
<term>Récepteur alpha des oestrogènes (génétique)</term>
<term>Tabagisme (génétique)</term>
<term>Tumeurs du sein (anatomopathologie)</term>
<term>Tumeurs du sein (génétique)</term>
<term>Tumeurs du sein (épidémiologie)</term>
<term>Études d'associations génétiques</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>CASP8 and FADD-Like Apoptosis Regulating Protein</term>
<term>Estrogen Receptor alpha</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs du sein</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Alcohol Drinking</term>
<term>Breast Neoplasms</term>
<term>Smoking</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Consommation d'alcool</term>
<term>Protéine de régulation de l'apoptose CASP8 et FADD-like</term>
<term>Récepteur alpha des oestrogènes</term>
<term>Tabagisme</term>
<term>Tumeurs du sein</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Tumeurs du sein</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Female</term>
<term>Gene-Environment Interaction</term>
<term>Genetic Association Studies</term>
<term>Genetic Predisposition to Disease</term>
<term>Humans</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Facteurs de risque</term>
<term>Femelle</term>
<term>Humains</term>
<term>Interaction entre gènes et environnement</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Prédisposition génétique à une maladie</term>
<term>Études d'associations génétiques</term>
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<front><div type="abstract" xml:lang="en"><p>Investigating the most likely causal variants identified by fine‐mapping analyses may improve the power to detect gene–environment interactions. We assessed the interplay between 70 single nucleotide polymorphisms identified by genetic fine‐scale mapping of susceptibility loci and 11 epidemiological breast cancer risk factors in relation to breast cancer. Analyses were conducted on up to 58,573 subjects (26,968 cases and 31,605 controls) from the Breast Cancer Association Consortium, in one of the largest studies of its kind. Analyses were carried out separately for estrogen receptor (ER) positive (ER+) and ER negative (ER–) disease. The Bayesian False Discovery Probability (BFDP) was computed to assess the noteworthiness of the results. Four potential gene–environment interactions were identified as noteworthy (BFDP < 0.80) when assuming a true prior interaction probability of 0.01. The strongest interaction result in relation to overall breast cancer risk was found between <italic>CFLAR</italic>
‐rs7558475 and current smoking (OR<sub>int</sub>
 = 0.77, 95% CI: 0.67–0.88, <italic>p</italic>
<sub>int</sub>
 = 1.8 × 10<sup>−4</sup>
). The interaction with the strongest statistical evidence was found between 5q14‐rs7707921 and alcohol consumption (OR<sub>int</sub>
 =1.36, 95% CI: 1.16–1.59, <italic>p</italic>
<sub>int</sub>
 = 1.9 × 10<sup>−5</sup>
) in relation to ER– disease risk. The remaining two gene–environment interactions were also identified in relation to ER– breast cancer risk and were found between 3p21‐rs6796502 and age at menarche (OR<sub>int</sub>
 = 1.26, 95% CI: 1.12–1.43, <italic>p</italic>
<sub>int</sub>
 =1.8 × 10<sup>−4</sup>
) and between 8q23‐rs13267382 and age at first full‐term pregnancy (OR<sub>int</sub>
 = 0.89, 95% CI: 0.83–0.95, <italic>p</italic>
<sub>int</sub>
 = 5.2 × 10<sup>−4</sup>
). While these results do not suggest any strong gene–environment interactions, our results may still be useful to inform experimental studies. These may in turn, shed light on the potential interactions observed.</p>
</div>
</front>
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<affiliations><list></list>
<tree><noCountry><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name>
<name sortKey="Barrdahl, Myrto" sort="Barrdahl, Myrto" uniqKey="Barrdahl M" first="Myrto" last="Barrdahl">Myrto Barrdahl</name>
<name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name>
<name sortKey="Behrens, Sabine" sort="Behrens, Sabine" uniqKey="Behrens S" first="Sabine" last="Behrens">Sabine Behrens</name>
<name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name>
<name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name>
<name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name>
<name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name>
<name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name>
<name sortKey="Castelao, J Esteban" sort="Castelao, J Esteban" uniqKey="Castelao J" first="J. Esteban" last="Castelao">J. Esteban Castelao</name>
<name sortKey="Chang Laude, Jenny" sort="Chang Laude, Jenny" uniqKey="Chang Laude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
<name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name>
<name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name>
<name sortKey="Cross, Simon" sort="Cross, Simon" uniqKey="Cross S" first="Simon" last="Cross">Simon Cross</name>
<name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name>
<name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name>
<name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name>
<name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
<name sortKey="Eilber, Ursula" sort="Eilber, Ursula" uniqKey="Eilber U" first="Ursula" last="Eilber">Ursula Eilber</name>
<name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name>
<name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name>
<name sortKey="Flesch Anys, Dieter" sort="Flesch Anys, Dieter" uniqKey="Flesch Anys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name>
<name sortKey="Gago Ominguez, Manuela" sort="Gago Ominguez, Manuela" uniqKey="Gago Ominguez M" first="Manuela" last="Gago-Dominguez">Manuela Gago-Dominguez</name>
<name sortKey="Gapstur, Susan M" sort="Gapstur, Susan M" uniqKey="Gapstur S" first="Susan M." last="Gapstur">Susan M. Gapstur</name>
<name sortKey="Garcia Losas, Montserrat" sort="Garcia Losas, Montserrat" uniqKey="Garcia Losas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name>
<name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M." last="Gaudet">Mia M. Gaudet</name>
<name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
<name sortKey="Goldberg, Mark S" sort="Goldberg, Mark S" uniqKey="Goldberg M" first="Mark S." last="Goldberg">Mark S. Goldberg</name>
<name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name>
<name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name>
<name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name>
<name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
<name sortKey="Jongen, Lynn" sort="Jongen, Lynn" uniqKey="Jongen L" first="Lynn" last="Jongen">Lynn Jongen</name>
<name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name>
<name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name>
<name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name>
<name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name>
<name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name>
<name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name>
<name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name>
<name sortKey="Schmidt, Marjanka" sort="Schmidt, Marjanka" uniqKey="Schmidt M" first="Marjanka" last="Schmidt">Marjanka Schmidt</name>
<name sortKey="Schoemaker, Minouk J" sort="Schoemaker, Minouk J" uniqKey="Schoemaker M" first="Minouk J." last="Schoemaker">Minouk J. Schoemaker</name>
<name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name>
<name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name>
<name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name>
<name sortKey="Thoene, Kathrin" sort="Thoene, Kathrin" uniqKey="Thoene K" first="Kathrin" last="Thoene">Kathrin Thoene</name>
<name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name>
<name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name>
</noCountry>
</tree>
</affiliations>
</record>

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{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:5601244
   |texte=   Gene–environment interactions involving functional variants: Results from the Breast Cancer Association Consortium
}}

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Serveur d'exploration sur les relations entre la France et l'Australie

Gene–environment interactions involving functional variants: Results from the Breast Cancer Association Consortium

Gene–environment interactions involving functional variants: Results from the Breast Cancer Association Consortium

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Descripteurs français

English descriptors

Abstract

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	Serveur d'exploration sur les relations entre la France et l'Australie
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